一項隨機雙盲安慰劑對照試驗:60%頭髮新生

植物茲醇β-sitosterol 與5-alpha-reductase抑制劑(鋸棕櫚Serenoa repens)治療AGA雄性禿(androgenetic alopecia)的有效性


什麼是Saw Palmetto鋸棕櫚?

鋸棕櫚,是一種看起來矮矮的棕櫚樹的植物,而他結的果實並不是椰子或是棗,而是果漿。

經過科學實驗分析,鋸棕櫚含有豐富的植物脂肪酸、類胡蘿蔔素、植物甾醇以及類黃酮。

當然,鋸棕櫚的化學分析還有很多物質,我們先提出幾個對於治療異常落髮,甚至是促進頭髮生長的化合物來解說。

Phytosterols植物茲醇 – 鋸棕櫚含有多種植物茲醇在內

β-sitosterol  β-谷甾醇        是一種天然的5-α-還原酶抑製劑。

stigmasterol   豆甾醇            一種不飽和 植物甾醇

lupeo                蛇麻醇酶        具有抗發炎、抗氧化劑效應、抗細胞突變、抗關節炎、抗瘧疾效應。

campesterol     油菜籽固醇     是一種植物甾醇,其化學結構類似於膽固醇。具有抗炎作用、降解骨關節炎。

cycloartenol     環阿屯醇         是存在於植物中甾醇類重要的三萜類化合物。三萜類化合物,是指存在於自然界中的有機化合物一大類目。



β-sitosterol β-谷甾醇  

有沒有科學證據 Beta Sitosterol有助於脫髮?

一項隨機雙盲安慰劑對照試驗:60%頭髮新生

植物茲醇β-sitosterol 與5-alpha-reductase抑制劑(鋸棕櫚Serenoa repens)治療AGA雄性禿(androgenetic alopecia)的有效性

Erratum in J Altern Complement Med. 2006 Mar;12(2):199.

Abstract

BACKGROUND:

Androgenetic alopecia (AGA) is characterized by the structural miniaturization of androgen-sensitive hair follicles in susceptible individuals and is anatomically defined within a given pattern of the scalp. Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic hyperplasia (BPH). Furthermore, AGA has also been shown to be responsive to drugs and agents used to treat BPH. Of note, certain botanical compounds have previously demonstrated efficacy against BPH. Here, we report the first example of a placebo-controlled, double-blind study undertaken in order to examine the benefit of these botanical substances in the treatment of AGA.

OBJECTIVES:

The goal of this study was to test botanically derived 5AR inhibitors, specifically the liposterolic extract of Serenoa repens (LSESr) and beta-sitosterol, in the treatment of AGA.

SUBJECTS:

Included in this study were males between the ages of 23 and 64 years of age, in good health, with mild to moderate AGA.

RESULTS:

The results of this pilot study showed a highly positive response to treatment. The blinded investigative staff assessment report showed that 60% of (6/10) study subjects dosed with the active study formulation were rated as improved at the final visit.

CONCLUSIONS:

This study establishes the effectiveness of naturally occurring 5AR inhibitors against AGA for the first time, and justifies the expansion to larger trials.

在這項研究中,已經明確的知道雄激素性脫髮(AGA)的發生是因為通過酶5-α還原酶(5AR)將睾酮(T)轉化為二氫睾酮(DHT)。

本研究的目的是測試植物衍生的5AR抑製劑,特別是鋸棕櫚Serenoa repens(LSESr)和β-谷甾醇的提取物,用於治療雄激素性脫髮(AGA)。

研究對象:年齡在23至64歲之間的男性,身體健康,輕度至中度AGA。

結果:這項試點研究的結果顯示對治療的反應非常積極。盲人調查工作人員評估報告顯示,在最終訪問中,60%研究對象配合主動研究製劑被評為改善。

結論:這項研究首次確定天然存在的5AR抑製劑對AGA的有效性,並證明擴大到更大的試驗。